| Risk Stratification | Genetics | Molecular Mutations |
|---|---|---|
| Low Risk | Inv(16), t(8;21) without 9q- or complex karyotype, t(16;16) | Normal karyotype with isolated NPM1 mutation |
| Intermediate Risk | Normal, +8, -Y, t(9;11), other karyotypes not in good or poor groups (<3 abnormalities) | C-KIT in t(8;21) or inv(16) |
| High Risk | -5/5q- or -7/7q-; t(8;21) with 9q- or complex karyotype; inv(3q); 11q23 abnormalities; 20q; 21q; 9q-; t(6;9); t(9;22); 17p abnormalities; complex karyotype (≥ 3 structural + numerical abnormalities) |
Normal karyotype with isolated FLT3 mutation |
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