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Correction of White Blood Cells in Bloody Cerebrospinal Fluid

Detected CSF
WBC Count
cells/μL
Blood WBC Count
×109/L
CSF RBC Count
cells/μL
Blood RBC Count
×1012/L
Calculation Result:
cells/μL

English Name

CSF WBC correction in blood contaminated CSF

Calculation Formula

Corrected CSF WBC Count = Detected CSF WBC Count - (Blood WBC Count * CSF RBC Count / Blood RBC Count)

Explanation

After 24 hours of bleeding, red blood cells dissolve, and bleeding stimulates the meninges, causing a significant increase in white blood cells. This cannot be calculated using the above formula. The types of increased cells start with neutrophils, followed by lymphocytes, and then monocytes.

References

Research Paper 1. Tunkel AR. Approach to the Patient with Central Nervous System Infection. In: Mandell GL, Bennett JE, Dolin R. (Eds). Principles and Practice of Infectious Diseases, 7th ed. Churchill Livingstone Elsevier, Philadelphia 2010. Vol 1, p.1183. Research Paper 2. Bonadio WA. The cerebrospinal fluid: physiologic aspects and alterations associated with bacterial meningitis. Pediatr Infect Dis J. 1992;11(6):423-31.
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