Common Sites and Manifestations of Spinal Cord Diseases

Lesion Location	Symptoms	Qualitative Diagnosis
Anterior horn	Lower motor neuron paralysis	Acute poliomyelitis Progressive muscular atrophy
Pyramidal tract	Upper motor neuron paralysis	Primary lateral sclerosis
Anterior horn, pyramidal tract	Upper and lower motor neuron paralysis	Amyotrophic lateral sclerosis
Posterior column, pyramidal tract	Deep sensory disturbance, upper motor neuron paralysis	Subacute combined degeneration
Posterior column	Deep sensory disturbance, sensory ataxia	Tabes dorsalis Pseudo-tabes (diabetes)
Spinocerebellar tract, posterior column, pyramidal tract	Ataxia, deep sensory disturbance, upper motor neuron paralysis	Hereditary ataxia
Central canal and anterior gray commissure	Loss of pain and temperature sensation, preserved touch (segmental dissociated sensory disturbance)	Syringomyelia, intramedullary tumor
Hemisection of the spinal cord	Brown-Sequard syndrome	Spinal cord compression, spinal cord injury
Transverse spinal cord lesion	Various sensory, motor, and autonomic dysfunctions below the lesion level	Acute myelitis, spinal hemorrhage, spinal cord injury, etc.