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Clinical Classification of Multiple Sclerosis

Type Clinical Features
Relapsing-Remitting (RR) Most common, multiple relapses, may have complete remission or leave mild sequelae after improvement, stable condition between relapses, good response to treatment, about 50% of patients transition to secondary-progressive type
Primary-Progressive (PP) Progressive worsening from onset, no remission, continuous gradual deterioration, no acute attacks, poor response to treatment
Secondary-Progressive (SP) Relapsing-remitting patients develop progressive worsening symptoms, with or without acute relapses
Progressive-Relapsing (PR) Rare, gradual progression after onset, with intermittent relapses

Explanation

In 1996, the National Multiple Sclerosis Society of the United States classified multiple sclerosis into relapsing-remitting, primary-progressive, secondary-progressive, and progressive-relapsing types based on clinical characteristics. This classification is related to treatment decisions and prognosis. Based on disease progression and prognosis, multiple sclerosis is divided into benign and malignant types. Benign multiple sclerosis patients have few relapses within 10-15 years of onset, and neurological function remains basically good; malignant multiple sclerosis has a rapid onset and progression, with rapid deterioration of neurological function leading to disability or death shortly after onset.

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