Comparison of Rh and ABO Hemolytic Disease
|
Rh Hemolytic Disease |
ABO Hemolytic Disease |
| Clinical Features |
Frequency |
Uncommon |
Common |
| Pallor |
Significant |
Mild |
| Edema |
Common |
Rare |
| Jaundice |
Severe |
Mild to Moderate |
| Hepatosplenomegaly |
Significant |
Mild |
| First Pregnancy Affected |
Rare |
About Half |
| More Severe in Subsequent Pregnancies |
Most |
Not Necessarily |
| Late Anemia |
Possible |
Rare |
| Laboratory Findings |
Maternal Blood Type |
Rh d, e, c |
O (Most) |
| Fetal Blood Type |
Rh D, E, C |
A or B (Most) |
| Anemia |
Significant |
Mild |
| Direct Antiglobulin Test |
Positive |
Modified Positive |
| Direct Antiglobulin Test |
Positive |
Positive |
| Red Cell Morphology |
Increased Nucleated Red Cells |
Increased Spherocytes |
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