| Diagnosis | Diagnostic Criteria |
|---|---|
| Primary Hypothyroidism | TSH>9 mIU/L; FT4<0.6 ng/dL |
| Primary Subclinical Hypothyroidism | TSH>9 mIU/L; FT4 normal (0.9-0.23 ng/dL) |
| TBG Deficiency | TSH normal (<9 mIU/L); FT4 normal (0.9-0.23 ng/dL); TT4 decreased (<5μg/dL); T3RUR>45% |
| Central Hypothyroidism | TSH<9 mIU/L or normal; FT4 decreased (<0.6ng/dL); TT4 decreased (<5μg/dL) |
Explanation
T4: 1μg/dL*12.87=1nmol/L;
FT4: 1ng/dL*12.87=1pmol/L
References
1. LaFranch SH. Approach to the diagnosis and treatment of neonatal hypothyroidism. J Clin Endocrinol Metab. 2011;96(10):2959-67.
2. Chinese Society of Endocrinology, Chinese Society of Perinatal Medicine. Guidelines for the diagnosis and treatment of thyroid diseases during pregnancy and postpartum. Chinese Journal of Endocrinology and Metabolism. 2012;28:354-71.
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