WHO Recommended Diagnostic Criteria for Crohn's Disease

Item	Clinical Manifestation	X-ray	Endoscopy	Biopsy	Resection Specimen
1. Discontinuous or segmental changes		+	+		+
2. Cobblestone appearance or longitudinal ulcers		+	+		+
3. Transmural inflammatory lesions	+(abdominal mass)	+(stricture)	+(stricture)		+
4. Non-caseating granulomas				+	+
5. Fissures, fistulas	+	+			+
6. Perianal lesions	+			+	+

Explanation

Diagnostic criteria: Suspected diagnosis if 1, 2, and 3 are present; confirmed diagnosis if one of 4, 5, or 6 is added; confirmed diagnosis if 4 is present along with any two of 1, 2, and 3.

References

Chinese Society of Gastroenterology Inflammatory Bowel Disease Collaboration Group. Consensus on the diagnosis and treatment of inflammatory bowel disease (2012, Guangzhou). Chinese Journal of Internal Medicine. 2012; 51(10):818-31.