The HEMORR₂HAGES Score is a clinical grading system used to predict the risk of bleeding in patients with atrial fibrillation. It integrates bleeding risk factors from existing grading systems into a modified grading system.

The specific meanings of the abbreviations are as follows:

• Hepatic or renal disease (H):
  Hepatic disease: cirrhosis, AST or APT elevated more than twice, or albumin < 3.6 g/dL
  Renal insufficiency: creatinine clearance < 30 ml/min
• Etanol abuse (E)
• Malignancy (M)
• Older (O): Age ≥ 75 years
• Reduced platelet count or function (R):
  Platelets < 75,000, regular use of antiplatelet drugs (e.g., daily aspirin) or NSAIDs; or cachexia
• Re-Bleeding (R)
• Hypertension (H): Uncontrolled hypertension
• Anemia (A)
• Genetic factors (G)
• Excessive fall risk (E)
• Stroke (S)