1. What is WBC Correction for NRBC?

The WBC correction for NRBC (nucleated red blood cells) is necessary when NRBCs are present in the blood sample. Since automated cell counters may count NRBCs as white blood cells, this correction provides a more accurate WBC count.

2. How Does the Calculator Work?

The calculator uses the following equation:

Where:

• Total WBC — Initial white blood cell count (cells/μL)
• NRBC — Nucleated red blood cells per 100 WBC

Explanation: The equation adjusts the total WBC count by removing the contribution from NRBCs that were mistakenly counted as WBCs.

3. Importance of WBC Correction

Details: Accurate WBC counting is crucial for proper diagnosis and monitoring of conditions like infection, inflammation, and hematologic disorders. NRBCs in peripheral blood may indicate bone marrow response to stress or pathology.

4. Using the Calculator

Tips: Enter the total WBC count from your lab results and the NRBC count per 100 WBC. Both values must be positive numbers.

5. Frequently Asked Questions (FAQ)

Q1: When is WBC correction for NRBC needed?
A: Correction is needed whenever NRBCs are present in the peripheral blood, typically when NRBCs ≥1 per 100 WBC.

Q2: What does the presence of NRBCs indicate?
A: NRBCs may indicate bone marrow stress, severe anemia, hypoxia, hemolysis, or other pathological conditions.

Q3: How are NRBCs counted?
A: NRBCs are typically counted manually during differential analysis of a peripheral blood smear.

Q4: What is the normal range for NRBCs?
A: Normally, NRBCs are not present in peripheral blood of adults. Their presence is always abnormal.

Q5: Does this correction affect other CBC parameters?
A: No, this correction only affects the WBC count. Other parameters like hemoglobin or platelet counts remain unchanged.