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BackMiconazole Data - Uses, Dosage, Drug class, Brand name, Warnings, etc
| Pharmacology |
Miconazole is an imidazole antifungal agent available in topical preparations and as an IV preparation solubilized in polyethoxylated castor oil (Cremophor EL). Inhibits fungal cytochrome P450, blocking ergosterol synthesis and disrupting fungal cell membranes. |
|---|---|
| Adult Dosage |
IV: - 1.2–3.6 g/day in 3 divided doses - Dilute in ≥200 mL D5W or NS, infuse over 30–60 min Topical for tinea infections: - Apply twice daily Vaginal Tablet for vulvovaginal candidiasis: - 100 mg at bedtime for 7 days - OR 200 mg at bedtime for 3 days Vaginal Cream for vulvovaginal candidiasis: - 5 g at bedtime for 7 days |
| Pediatric Dosage |
IV: - <1 yr: 15–30 mg/kg/day - 1–12 yr: 20–40 mg/kg/day - Do not exceed 15 mg/kg/dose Topical: - Same as adult dosage Vaginal Cream/Tablet: - <12 yr: Safety and efficacy not established - ≥12 yr: Same as adult dosage |
| Dosage Forms |
- Injection: 10 mg/mL - Topical Cream, Spray, Powder: 2% - Vaginal Cream: 2% - Vaginal Suppository: 100 mg, 200 mg Combination Packages: - Monistat Dual-Pak, M-Zole 3: Vaginal Suppository 200 mg (#3) + Vaginal Cream 2% - Monistat 7: Vaginal Suppository 100 mg (#7) + Vaginal Cream 2% |
| Adverse Reactions |
IV: - Frequent: Phlebitis, pruritus, nausea, vomiting, fever, chills, rash - Serious (likely vehicle-related): Cardiorespiratory arrest, hyponatremia |
| Notes |
- Restrict IV use to fungal infections resistant to amphotericin B (e.g., Scedosporium apiospermum) due to serious toxicity and questionable efficacy - Topical/vaginal effects similar to clotrimazole |
References
Hand of Clinical Drug Data