Nystatin Data - Uses, Dosage, Drug class, etc

Pharmacology	Nystatin is a polyene antifungal agent, similar to amphotericin B but too toxic for parenteral use. Negligible oral absorption; no absorption through intact skin or mucous membranes.
Adult Dosage	PO for oral candidiasis: - Suspension: 400,000–600,000 units 4 times daily (swish and swallow) - Troches: 200,000–400,000 units 4–5 times/day - Continue ≥48 hr post-symptom resolution and negative cultures - Immunocompromised: May require 10–14 days - Vaginal tablet (used orally): 100,000 units for prolonged contact PO for GI candidiasis: - 500,000–1,000,000 units 3 times daily Vaginal for candidiasis: - 100,000 units daily or twice daily for 2 weeks
Pediatric Dosage	PO for candidiasis: - Newborns: 100,000 units 4 times daily - Older infants/children: 200,000–400,000 units 4 times daily Topical: - Same as adult dosage
Dosage Forms	- Oral Tablet: 500,000 units - Oral Troche: 200,000 units - Suspension: 100,000 units/mL - Topical Cream, Ointment, Powder: 100,000 units/g - Vaginal Tablet: 100,000 units
Adverse Reactions	Nontoxic via oral, topical, vaginal routes. Rare: - Allergic sensitization
Notes	Nyotran (investigational, Aronex): Injectable liposomal formulation under study for candidemia, cryptococcal meningitis, aspergillosis.