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BackVoriconazole Data - Uses, Dosage, Drug class, Brand name, Warnings, etc
| Pharmacology |
Voriconazole is an azole antifungal, a derivative of fluconazole, with the same mechanism of action. Superior activity against Candida albicans, C. krusei, and C. glabrata. Activity against Aspergillus spp. equivalent to itraconazole. Also active against Pseudallescheria boydii and Scedosporium apiospermum. |
|---|---|
| Adult Dosage |
PO or IV: - 50–400 mg/day (investigational use) |
| Pediatric Dosage |
PO or IV: - Limited data; 7–10 mg/kg/day used investigationally |
| Dosage Forms | Not yet available (investigational at time of data). |
| Pharmacokinetics |
Bioavailability: - Oral: ~90% Steady-State Plasma Levels: - 2.1–4.8 mg/L with 200 mg twice daily Protein Binding: - 51–67% Distribution: - Vd = 2 L/kg Metabolism: - Hepatic, primarily via CYP2C9 and CYP3A4 Elimination Half-life: - ~6 hr Excretion: - <5% unchanged in urine; detectable in urine/feces for days post-prolonged therapy |
| Adverse Reactions |
Frequent: - Reversible mild to moderate dose-related visual disturbances - Elevations in hepatic enzymes Rare: - Photosensitivity (1 case reported) May interact with drugs affecting or metabolized by CYP2C9 and CYP3A4; more data needed. |
References
Hand of Clinical Drug Data