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MDRD CKD-EPI (Creatinine) CKD-EPI (Cystatin C) CKD-EPI (Creatinine-Cystatin C) Cockcroft-Gault

eGFR Glomerular Filtration Rate
(2021 CKD-EPI Creatinine)

International Units: μmol/L, US Units: mg/dL
Age
years
Serum Creatinine
Glomerular Filtration Rate
mL/min/1.73m2
2021 eGFR = 142 x (Scr/A)B x (0.9938)Age x C
1) Female
C value: 1.012

Scr ≤0.7mg/dL

Scr >0.7mg/dL

A = 0.7

B = -0.241

A = 0.7

B = -1.2
2) Male
C value: 1

Scr ≤0.9mg/dL

Scr >0.9mg/dL

A = 0.9

B = -0.302

A = 0.9

B = -1.2
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Formula Explanation

CKD-EPI (Creatinine) was developed by Levey et al. in 2009 and validated by Inker et al. in 2012, found to be more accurate than the MDRD equation. Recent debates about its use in Black patients (race being a social construct rather than a biological one) led Inker et al. to update the CKD-EPI formula in 2021 to remove race from the equation.

References

Research Paper 1. Levey AS, Stevens LA, Schmid CH, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150(9):604-12. Research Paper 2. Inker LA, Schmid CH, Tighiouart H, et al. Estimating glomerular filtration rate from serum creatinine and cystatin C. N Engl J Med. 2012;367(1):20-9. Research Paper 3. Inker LA, Eneanya ND, Coresh J, et al. New creatinine- and cystatin c-based equations to estimate gfr without race. N Engl J Med. Published online September 23, 2021. Research Paper 4. CKD-EPI Creatinine Equation (2021) Research Paper 5. 2012 KDIGO Clinical Practice Guideline for Anemia in Chronic Kidney Disease
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